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KaliVir Immunotherapeutics
KaliVir Immunotherapeutics is a clinical-stage biotechnology company at the forefront of developing next-generation oncolytic immunotherapies. By harnessing the unique advantages of the vaccinia platform, KaliVir engineers optimized viral backbones to create innovative candidates for cancer treatment. The Company's proprietary Vaccinia Enhanced Template (VET™) platform integrates multiple genetic modifications, allowing for the systemic delivery of oncolytic vaccinia candidates and the targeted expression of therapeutic transgenes within tumors. KaliVir is headquartered in Pittsburgh, Pennsylvania.
What is your next catalyst (value inflection) update?
Near-term catalysts are primarily for the VET3-TGI program: Initial and complete Phase 1data monotherapy data in intratumoral patients, initial data from combination therapy patients in both intratumoral and intravenous delivery patients
Year Founded
2019
Lead Product in Development
VET3-TGI is a novel oncolytic immunotherapy developed using KaliVir’s proprietary VET™ platform, designed to selectively replicate in tumor cells, stimulate local immune responses and remodel the immunosuppressive tumor microenvironment through the expression of IL-12 and a TGFβ inhibitor. By combining potent local immune activation with blockade of a key immunosuppressive pathway, the program is designed to drive durable, systemic anti-tumor responses across solid tumors.
Development Phase of Lead Product
Phase I
Number of Unlicensed Products Looking for Licensing
KaliVir has 2 product candidates available for licensing, including one asset that is currently in clinical development and a second, earlier-stage program that has not yet entered the clinic.
CEO/Top Company Official
Helena Chaye, Ph.D.,, J.D. is Chief Executive Officer and a Board Director
When you expect your next catalyst update?
Near-term catalysts are primarily for the VET3-TGI program with initial Phase 1 expansion monotherapy data in intratumoral patients in 1H/Mid-26
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