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KaliVir Immunotherapeutics is a clinical-stage biotechnology company at the forefront of developing next-generation oncolytic immunotherapies. By harnessing the unique advantages of the vaccinia platform, KaliVir engineers optimized viral backbones to create innovative candidates for cancer treatment. The Company's proprietary Vaccinia Enhanced Template (VET™) platform integrates multiple genetic modifications, allowing for the systemic delivery of oncolytic vaccinia candidates and the targeted expression of therapeutic transgenes within tumors. KaliVir is headquartered in Pittsburgh, Pennsylvania.
Year Founded
2019
Next catalyst (value inflection) update
Near-term catalysts are primarily for the VET3-TGI program: Initial and complete Phase 1data monotherapy data in intratumoral patients, initial data from combination therapy patients in both intratumoral and intravenous delivery patients
Expected time of next catalyst update
Near-term catalysts are primarily for the VET3-TGI program with initial Phase 1 expansion monotherapy data in intratumoral patients in 1H/Mid-26
City
Pittsburgh
Country
United States
Company CEO or top company official
Helena Chaye, Ph.D.,, J.D. is Chief Executive Officer and a Board Director
Development Phase of Primary Product
Phase I
Lead Product in Development
VET3-TGI is a novel oncolytic immunotherapy developed using KaliVir’s proprietary VET™ platform, designed to selectively replicate in tumor cells, stimulate local immune responses and remodel the immunosuppressive tumor microenvironment through the expression of IL-12 and a TGFβ inhibitor. By combining potent local immune activation with blockade of a key immunosuppressive pathway, the program is designed to drive durable, systemic anti-tumor responses across solid tumors.
Number of Unlicensed Products
KaliVir has 2 product candidates available for licensing, including one asset that is currently in clinical development and a second, earlier-stage program that has not yet entered the clinic.
Therapeutic Area
Oncology
Website
http://www.kalivir.com
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